Epithalon, a peptide telomerase activator, has been extensively studied and is believed to have significant potential for longevity. First characterized and created by Russian researchers in the 1980s, it has been the subject of much investigation due to its potential in mitigating DNA damage, regulating neuronal activity, and promoting telomere extension to potentially achieve anti-aging outcomes within cells.
Epithalon Peptide: What is it?
Epithalon, also known as Epitalon, is a chain of four amino acids: alanine, glutamic acid, aspartic acid, and glycine. The compound is obtained from a peptide complex, epithalamin, generated from bovine pineal glands. Its main mechanism of action is within the neuroendocrine system.
The investigation of epithalamin and Epithalon began in the 1980s, primarily led by Vladimir Khavinson, a highly skilled scientist renowned for his groundbreaking research on other peptide bioregulators, such as Vilon. Multiple studies suggest that Epithalon may have anti-aging potential on cellular divisions.
Studies suggest that one of the primary processes by which Epithalon is believed to exert its potential is telomerase activity induction and telomere elongation, which serve as protective structures inside DNA. Telomerase facilitates cellular proliferation and rejuvenation, supporting the hypothesis that Epithalon may contribute to the extension of an organism’s lifetime.
Although clinical research on Epithalon is lacking, it is worth noting that epithalamin has received attention for its potential in studies within the context of symptoms associated with menopause, anovulatory infertility, and hormone-dependent malignancies.
Epithalon Peptide Potential
A thorough investigation into the possible action of the Epithalon indicates that it may play a crucial role in anti-aging mechanisms in the cell. Nevertheless, it is important to acknowledge that most studies on Epithalon peptides have been conducted by Professor Khavinson and his research team and have not yet been verified by other sources.
Drawing upon the existing body of research, this paper examines the possible anti-cell aging, sleep-enhancing, and disease-fighting potential of Epithalon peptide.
Epithalon Peptide and Cell Aging
Telomeres are defensive structures located at the termini of chromosomes that gradually decrease in length with each round of cell division. Reducing telomere length has been linked to a decrease in longevity and an increased susceptibility to certain diseases. Telomerase, an enzyme, extends the telomeres in some cells.
Researchers have been interested in evaluating Epithalon for anti-aging impact due to its potential to stimulate telomerase activity and extend telomeres. Extensive studies have been conducted in this area.
A significant investigation conducted by Khavinson et al. indicated that introducing Epithalon into telomerase-negative fetal fibroblast cells appeared to have resulted in the elongation of telomeres and the stimulation of telomerase. Based on these findings, researchers speculated that Epithalon may have the potential to extend the lifespan of cells and organisms.
According to a 2007 study conducted by Vinogradova et al., Epithalon in rats exposed to natural and steady lighting seemed to have increased lifetime due to a decrease in spontaneous tumors.
Khavinson et al. conducted an eight-year study on epithalamin, suggesting that the peptide may enhance cardiovascular, endocrine, immunological, and neurological system parameters. The researchers hypothesized that epithalamin may extend old research models’ lifespans.
Korkushko et al. conducted randomized long-term research study spanning 12 years, which suggested a significant association between Epithalon and a “geroprotective effect.” This effect was theorized to extend the lifetime in heart disease and accelerated cardiovascular system aging.
In the subsequent investigation, the researchers speculated that the research models exposed to Epithalon had a mortality rate of 1.6-1.8 times lower compared to the control group.
Epithalon Peptide and Sleep Cycles
Research indicates that the investigation of Epithalon’s impact on sleep quality is motivated by the peptide’s potential to enhance melatonin levels, a hormone produced in the pineal gland that plays a crucial role in regulating sleep quality. Investigations purport that the appropriate control of this hormone may reinstate the sleep-wake cycle, and regulate and increase sleep duration.
An experiment conducted in 2007 suggested that Epithalon may restore the circadian rhythm and elevate nocturnal melatonin levels in animal research models of pineal gland failure, including monkeys. According to the research authors, Epithalon seems to have the potential to impact sleep cycle regulation and thereby, sleep quality.
Epithalon Peptide and Tumors
Epithalamin studies suggest that Epithalon may have antioxidant potential to control cytokines and C-reactive protein. This has generated research interest in its potential in research related to various inflammatory conditions, such as arthritis and ulcerative colitis.
Previous research on animals has purported that the peptide may have anti-tumor potential and may possibly suppress the development of carcinogenic receptors. In a 1997 study, the researchers theorized that the peptide may potentially reduce tumor growth in ovarian, uterine, and cervical cancer while enhancing cellular immunity.
Researchers interested in more high-quality research peptides are encouraged to visit this website.
References
[i] Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, Mironova E, Pulcini R, Robuffo I, Bologna G, Simeone P, Lanuti P, Guarnieri S, Trofimova S, Procopio AD, Toniato E. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. International Journal of Molecular Sciences. 2022; 23(7):3607. https://doi.org/10.3390/ijms23073607
[ii] Epithalamin and epithalon cognitive vitality for researchers [Internet]. [cited 2023Jan28]. Available from: https://www.alzdiscovery.org/uploads/cognitive_vital ity_media/Epithalamin-and-Epithalon-Cognitive-Vitality-For-Researchers.pd
[iii] Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2. doi: 10.1023/a:1025493705728. PMID: 12937682
[iv] Vinogradova IA, Bukalev AV, Zabezhinski MA, Semenchenko AV, Khavinson VKh, Anisimov VN. Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes. Bull Exp Biol Med. 2007 Dec;144(6):825-30. doi: 10.1007/s10517-007-0441-z. PMID: 18856211.
[v] Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003 Jun-Aug;24(3-4):233-40. PMID: 14523363.
[vi] Korkushko OV, Khavinson VKh, Shatilo VB, Antonyuk-Shcheglova IA. Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging. Bull Exp Biol Med. 2006 Sep;142(3):356-9. English, Russian. doi: 10.1007/s10517-006-0365-z. PMID: 17426848.
[vii] Korkushko OV, Lapin BA, Goncharova ND, Khavinson VKh, Shatilo VB, Vengerin AA, Antoniuk-Shcheglova IA, Magdich LV. [Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people]. Adv Gerontol. 2007;20(1):74-85. Russian. PMID: 17969590.
[viii] Anisimov VN, Arutjunyan AV, Khavinson VK. Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals. Neuro Endocrinol Lett. 2001;22(1):9-18. PMID: 11335874.
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